Aminoacyl adenylate mimics as novel antimicrobial and antiparasitic agents

摘要

Certain novel aminoacyl adenylate mimics are described. An exemplary compound of this invention is [S-(R*,R*)]-3,6-anhydro-1,2-dideoxy-1-[5-[4-[(5-nitro-2-thienyl)ethynyl]phenyl]-2H-tetrazol-2-yl]-D-allo-heptitol 7-(2-amino-3-methyl-1-oxopentyl)sulfamate. These compounds inhibit isoleucyl-tRNA synthetases and are useful as antimicrobial and antiparasitic agents.