| 摘要 |
FIELD: medicine, more particularly prophylacsis and medical treatment of thrombosis. SUBSTANCE: present invention describes pseudopeptides or salts thereof of formula I: <EMI ID=0.65 HE=9 WI=60 TI=CHI> wherein R<SB>1</SB> is COOH, COO L<SB>1</SB>: X is CH<SB>2</SB>, or R<SB>1</SB> and X together are <EMI ID=0.66 HE=9 WI=15 TI=CHI>; Y is (CH<SB>2</SB>)<SB>m</SB>, m is 1 or 2, A is -CO-(CH<SB>2</SB>)<SB>p</SB>-C<SB>6</SB>H<SB>4</SB>-C-(=NH)NH<SB>2</SB> wherein p is 0 or 1; B is -CO-(CH<SB>2</SB>)<SB>q</SB>-R<SB>3</SB> wherein q is 1 or 2; R<SB>3</SB> is (C<SB>1</SB>-C<SB>4</SB>) alkyl, 1-adamantyl, (C<SB>1</SB>-C<SB>4</SB>) alkoxyphenyl or B is -SO<SB>2</SB>-(CH<SB>2</SB>)<SB>r</SB>-R<SB>4</SB> wherein is 0,1 or 2; R<SB>4</SB> = n-(C<SB>1</SB>-C<SB>4</SB>) is alkoxyphenyl. Present invention also describes two methods of preparing compounds I and pharmaceutical composition comprising as active ingredient pseudopeptide of formula I or salt thereof in effective amount. EFFECT: improved properties of the pharmaceutical composition. 9 cl, 2 tbl$
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