N-BENZYLAZOLIUM DERIVATIVES

摘要

N-Benzylazolium derivatives of the general formula (I), (see fig.I) wherein Q is the remainder of an azole compound of the formula II (see fig.II) possessing antifungal activity; Z is nitrogen or methine; R1 and R2 are each independently a hydrogen atom or a group -OY ¢in which Y is a group easily hydrolyzable under physiological condition!; R3 and R4 are each independently a hydrogen or halogen atom, lower alkyl, lower alkoxy, lower alkylthio, (lower alkylcarbonyl)thiomethyl, carboxy or methoxycarbonyl; and X- is a pharmaceutically acceptable anion, as well as salts, hydrates or solvates of the compounds of the general formula (I) have antifungal properties.