发明名称 |
Novel liposome complexes for increased systemic delivery |
摘要 |
Highly efficient cationic liposomes have been developed as an improved delivery system for biologicallyactive reagents. A novel structure, the sandwich liposome, is formed and comprises one or more biologically active agents internalized between two bilomellar liposomes. This structure protects the incoming agent and accounts for the high efficiency of in vivo delivery and for the broad tissue distribution of the sandwich liposome complexes. These novel liposomes are also highly efficient carriers of nucleic acids. By using extruded DOTAP:cholesterol liposomes to form complexes with DNA encoding specific proteins, expression has been improved dramatically. Highest expression was achieved in the lung, while increased expression was detected in several organs and tissues. |
申请公布号 |
AU4050297(A) |
申请公布日期 |
1998.03.06 |
申请号 |
AU19970040502 |
申请日期 |
1997.08.01 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED |
发明人 |
NANCY SMYTH-TEMPLETON;GEORGE N PAVLAKIS |
分类号 |
A61K9/127;A61K47/16;A61K47/28;A61K47/48;A61K48/00;C12N15/88 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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