发明名称 |
INTEGRIN ANTAGONISTS |
摘要 |
This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. The vitronectin receptor antagonist compounds of the present invention are .alpha.v.beta.3 antagonists, .alpha.v.beta.5 antagonists or dual .alpha.v.beta.3/.alpha.v.beta.5 antagonists useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation and tumor growth.
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申请公布号 |
CA2263999(A1) |
申请公布日期 |
1998.03.05 |
申请号 |
CA19972263999 |
申请日期 |
1997.08.25 |
申请人 |
MERCK & CO., INC. |
发明人 |
HOFFMAN, WILLIAM F.;MEISSNER, ROBERT S.;PERKINS, JAMES J.;NAYLOR-OLSEN, ADEL M.;ASKEW, BEN C.;COLEMAN, PAUL J.;HARTMAN, GEORGE D.;DUGGAN, MARK E.;HUTCHINSON, JOHN H. |
分类号 |
A61K31/4375;A61K31/444;A61K31/454;A61K31/4545;A61K31/4709;A61K31/497;A61K31/506;A61K38/00;A61P3/10;A61P3/14;A61P9/08;A61P9/10;A61P19/10;A61P27/02;A61P29/02;A61P35/00;A61P43/00;C07D471/04;C07D519/00;C07K5/02;(IPC1-7):C07D401/06;A61K31/415;A61K31/435 |
主分类号 |
A61K31/4375 |
代理机构 |
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