| 摘要 |
<p>Proteins having a telomerase activity and being useful in screening telomerase inhibitors, developing diagnostic methods with the use of antibodies, etc. Conjugated proteins including proteins having a telomerase activity which have the following physicochemical properties: function and substrate specificity: catalyzing the elongation of the telomere DNA 3'-OH terminal of chromosomes of eukaryotes; molecular weight: ranging from about 40 to about 120 kD, in particular, about 110, 58 and/or 45kD in some cases, as determined by SDS-PAGE; inactivation: inactivated by treating with RNase; and characteristic: binding to mouse telomerase RNA.</p> |
