摘要 |
<p>A method for making a medical device having a glycoprotein immobilized on a substrate surface is provided. The method comprises the steps of: (a) oxidizing 1,2-dihydroxy moieties with a periodate to form an aldehyde-functional material; (b) combining the aldehyde-functional material with an amino-functional material to bond the two materials together through an imine moiety; and (c) reacting the imine moiety with a reducing agent to form a secondary amine.</p> |