STILBENE DERIVATIVES AS PPAR ALPHA/GAMMA DUAL AGONISTS AND PREPARATION METHOD THEROF

摘要

A stilbene derivatives as PPAR(peroxisome proliferator activation acceptor) alpha/gamma dual agonists is provided for treatment and prevention of obesity, diabetes, skin aging, skin wrinkle and skin hydration. A stilbene derivatives represented by the formula 1 is obtained by reacting a compound represented by the formula 2 and a compound represented by the formula 3. In the formula 1, 2 and 3, R^1 indicates an isoflavonoid group represented by the formula 1-a; R^2 is hydrogen, methyl, ethyl, tert-butyl, benzyl, methoxymethyl, trimethylsilyl, tert-butyldiphenylsilyl, tert-butyldimethylsilyl or triisopropylsilyl; R^3 shows -F, -CF3, -CH3 or -OCH3; A represents cis-, trans- isomers; m is an integer of 0~2; n is an integer of 1~5; p is integer of 0~2; and X shows a halogen atom.