摘要 |
PROBLEM TO BE SOLVED: To safely obtain the subject compound in a high yield and in a high purity in one process by dropping an acid to an aldehyde derivative in the presence of a cyano compound and subsequently hydrolyzing the reaction product with a mineral acid. SOLUTION: This method for producing a mandelic acid derivative comprises dropping an acid (A) to an aldehyde derivative of the formula (R<1> -R<3> are each H, a halogen, a 1-5C alkyl, a 1-5C alkoxy, hydroxyl group, phenyl which may be substituted) in the presence of (B) a cyano compound in a solvent and subsequently hydrolyzing the obtained corresponding mandelonitrile derivative with a mineral acid. The solvent is especially preferably ethyl acetate, and is used in an amount of 0.5-5 weight times that of the component A. The component B includes sodium cyanate and potassium cyanate, and is used in an amount of 1-4 moles, preferably 1.1-1.3 moles, per mole of the component A. Thereby, the mandelic acid derivative useful as a synthetic intermediate for medicines can safely be obtained in a high yield and in a high purity in only one process. |