TRICYCLIC COMPOUNDS, THEIR PRODUCTION AND USE

摘要

A pharmaceutical composition for treating or preventing proliferative glomerulonephritis, which comprises a compound of the formula: <IMG> (see fig.I) wherein ring A is a nitrogen-containing heterocyclic ring, having two nitrogen atoms as the hetero-atoms, which may be substituted with oxo or thioxo; ring Q may be substituted; Y is an optionally substituted hydrocarbon group, an optionally substituted hydroxy group or an optionally substituted mercapto group; and Rl is a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group or an acyl group, or a salt thereof, and a novel compound of the formula: <IMG> (see fig.II) wherein ring Aa may have one oxo group; D is a bond or an optionally substituted divalent hydrocarbon group; ring W is an optionally substituted nitrogen-containing heterocyclic ring; ring Q may be substituted; and R3 is an electron-withdrawing group, or a salt thereof, which have excellent PDGF-inhibiting activities, activities of ameliorating renal diseases and activities of lowering lipid level and are less toxic and are useful as a preventive and treating agent for cardisvascular diseases.