| 摘要 |
The present invention relates to compounds of Formula I, in which A and B are independently CH 2 , O, S, NH, C=O, C=NH, C=S or C=N-OH; X is NH, O, S, C=O or CH 2 and R 1 -R 5 are as defined in claim 1, which are P2Y 12 receptor antagonists and useful for treating, alleviating and/or preventing diseases and disorders related to P2Y 12 receptor function as well as pharmaceutical compositions comprising such compounds and methods for preparing such compounds. The present invention is further directed to the use of these compounds, alone or in combination with other therapeutic agents, for the alleviation, prevention and/or treatment of diseases and disorders, especially the use as antithrombotic agents for inhibiting platelet aggregation. |
