ALPHA-HELIX MIMETIC WITH FUNCTIONALIZED PYRIDAZINE

摘要

The synthesis of new alpha-helix scaffolds mimicking i, i+3 or i+4, i+7 residues, was accomplished. The common pyridazine heterocycle originates from the easily available dimethyl pyridazine-3,6-dicarboxylate building block. These scaffolds may be thought of as synthetic counterparts of amphiphilic alpha-helices having a hydrophilic face along one side and a hydrophobic face along the other side of the helix.