NOVEL COUMARIN QUINOLONE CARBOXYLIC ACIDS AND PROCESSES FOR THE PREPARATION THEREOF

摘要

The present invention relates to novel coumarin quinolone carboxylic acids wherein the pyridone system is fused in 3,4-, 6,7- and 7,8-positions of the coumarin system, of the general formula I wherein R1R2=-NHCH=C(CO2R6)CO, R3=NO2 or NH2, R4=R5=H, R6=H or C2H5; R1R2=-NHCH=C(CO2R6)CO, R3=R4=H, R5=F, R6=H or C2H5; R1R2=-CO(CO2R6)C=CHNH, R3=R4=R5=H, R6=H or C2H5; R1R2=R3R4=-NHCH=C(CO2R6)CO, R5=H, R6=H or C2H5; R1=H or OH, R2=R5=H, R3R4=-NHCH=C(CO2R6)CO, R6=H or C2H5; R1- OH, R2=R3=H, R4R5=-CO(CO2R6)C=CHNH, R6=H or C2H5; R1=R5=H, R2=CH3 or CF3, R3R4=-CO(CO2R6)C=CHNH, R6=H or C2H5, as well as pharmaceutically acceptable salts thereof. The object of the invention are also processes for the preparation of novel coumarin quinolone carboxylic acids and the biological action thereof.