| 摘要 |
<p>This invention relates to compounds having general structure (II) that inhibit the binding of E-selectin and/or P-selectin to sialyl-Lewisx or sialyl-Lewisa presented on a cell surface. This invention also relates to methods of inhibiting the binding of E-selectin and/or P-selectin to sialyl-Lewisx or sialyl-Lewisa presented on a cell surface using said compounds, and to pharmaceutically active compositions comprising compounds that inhibit the binding of E-selectin to sialyl-Lewisx. This invention also concerns methods of using said compounds for treatment of septic shock, ARDS, Crohn's disease, chronic inflammatory disease such as psoriasis and rheumatoid arthritis, and reperfusion injuries that occur following heart attacks, strokes and organ transplants.</p> |
