发明名称 |
PREPARATION OF N-MONOFLUOROALKYL TROPANES. |
摘要 |
The present invention relates to an improved synthesis of N-monofluoroalkyl tropanes using fluoroalkyl iodides or fluoroalkyl sulfonate esters. The invention also provides the use of such method to prepare the non-radioactive tropane intermediate FP-CIT, and its subsequent conversion to the 123I-labelled radiopharmaceutical DaTSCANTM (123I-ioflupane). Also provided is the use of fluoroalkyl iodides or fluoroalkyl sulfonate esters in the alkylation method of the invention. |
申请公布号 |
MX339670(B) |
申请公布日期 |
2016.06.03 |
申请号 |
MX20120007038 |
申请日期 |
2010.12.15 |
申请人 |
GE HEALTHCARE LIMITED |
发明人 |
Lorenzo Williams;Gunnar Keilen;Jarle Andre Haugan |
分类号 |
C07D451/02;C07C19/16;C07F7/22 |
主分类号 |
C07D451/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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