METHOD OF PREPARING AND/OR PURIFYING CLAVULANIC ACID OR PHARMACEUTICALLY ACCEPTABLE SALTS OR ESTERS THEREOF CLAVULANIC ACID SALT WITH AMINO ACID

摘要

FIELD: organic chemistry. SUBSTANCE: claimed method or preparing and/or purifying clavulanic acid or pharmaceutically acceptable salts or esters thereof by contacting crude clavulanic acid or its labile derivative in organic solvent with amino acid of formula NH2-R wherein R is amino acid residue such aminophenyl acetic acid or arginine to which carboxy group of amino acid is esterified, recovery of clavulanic acid salt with amino acid of formula II, conversion of said amino acid into clavulanic acid or salt or ester thereof. The present invention also describes clavulanic acid salts with amino acid of formula II as intermediates for preparing and/or purifying clavulanic acid or esters thereof. EFFECT: more efficient preparation method and greater antibiotic activity of clavulanic acid derivatives. 40 cl, 1 tbl