发明名称 |
Ortho-substituted benzoylguanidines, process for their preparation, their use as medicament or diagnostic agent, as well as medicaments containing them |
摘要 |
<p>Ortho-substituted benzoylguanidines of the formula I <IMAGE> where: R(1) is equal to halogen, alkyl, -X-R(6), where X is equal to O, S, NR(7) or Y-ZO and R(6) is equal to H, (cyclo)(halo)alkyl(methyl), -CnH2n-phenyl, R(3) is equal to H, -X-R(6), R(2) and R(4) are equal to R(11)-SO1-2-, (di)-alkyl-N-SO2-, or one of the two radicals R(2) or R(4) is equal to hydrogen or is defined as R(1), R(5) is equal to H, methyl, F, Cl, methoxy, and their pharmaceutically acceptable salts. They are obtained by a process in which compounds of the formula II <IMAGE> in which R(1) to R(5) have the meaning mentioned and L represents a leaving group which can be easily substituted nucleophilically, are reacted with guanidine. The compounds I are used for producing a medicament for the treatment and the prophylaxis of heart-rhythm disorders and ischaemically induced damage, as well as for producing a medicament for the inhibition of cell proliferation.</p> |
申请公布号 |
GR3025523(T3) |
申请公布日期 |
1998.02.27 |
申请号 |
GR19970403172T |
申请日期 |
1997.11.26 |
申请人 |
HOECHST AKTIENGESELLSCHAFT |
发明人 |
LANG, HANS-JOCHEN, DR.;WEICHERT, ANDREAS, DR.;ENGLERT, HEINRICH, DR.;SCHOLZ, WOLFGANG, DR.;ALBUS, UDO, DR.;LANG, FLORIAN, PROF. DR. |
分类号 |
A61K31/155;A61K31/18;A61P1/16;A61P3/08;A61P3/10;A61P9/00;A61P9/04;A61P9/06;A61P9/08;A61P9/10;A61P9/12;A61P13/02;A61P15/00;A61P35/00;C07C311/21;C07C311/37;C07C311/39;C07C311/47;C07C317/42;C07C317/44;C07C323/65;C07D295/155;C07D295/22;C07D295/26;(IPC1-7):C07C317/42 |
主分类号 |
A61K31/155 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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