| 发明名称 |
SUBSTITUTED PYRROLIDIN-3-YL-ALKYL-PIPERIDINES USEFUL AS TACHYKININ ANTAGONISTS |
| 摘要 |
<p>The present invention relates to substituted pyrrolidinyl-3-yl-alkyl-piperidines, their stereoisomers, and pharmaceutically acceptable salts thereof and processes for preparation of the same. The compounds of the present invention are useful in their pharmacological activities such as tachykinin antagonism, especially substance P and neurokinin A antagonism, and the like. Compounds having the property of tachykinin antagonism are indicated for conditions associated with neurogenic inflammation and other diseases described herein.</p> |
| 申请公布号 |
GR3025475(T3) |
申请公布日期 |
1998.02.27 |
| 申请号 |
GR19970403124T |
申请日期 |
1997.11.26 |
| 申请人 |
MERRELL DOW PHARMACEUTICALS INC. |
发明人 |
BURKHOLDER, TIMOTHY, P.;LE, TIEU-BINH;KUDLACZ, ELIZABETH, M.;MAYNARD, GEORGE D. |
| 分类号 |
C07D487/10;A61K31/437;A61K31/4427;A61K31/443;A61K31/4433;A61K31/445;A61K31/451;A61K31/454;A61K31/4545;A61K31/535;A61P1/04;A61P9/00;A61P9/08;A61P11/00;A61P11/06;A61P17/00;A61P25/00;A61P25/18;A61P25/20;A61P25/28;A61P27/16;A61P29/00;A61P37/08;A61P43/00;C07D401/06;C07D401/14;C07D405/14;C07D409/14;C07D471/10;(IPC1-7):C07D401/06 |
主分类号 |
C07D487/10 |
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