| 摘要 |
A method and apparatus for the analysis of neoplasia in tissue and for preinvasive cancer and for analysis of the effect of chemopreventive agents with respect to neoplasia. An interactive optical system (11a) acquires a plurality of abutting optical frames (413) along the basal layer (411) which are then imaged and digitized. A mouse is used to edit a reduced size mosaic (441) of the optical frames (433) in order to erase frames with limited analysis value. The mouse is also used to remove unwanted cell objects from full size frames (426). For each frame, area (505), sum optical density (507), run length (509), configurable run length (511), valley-slope-peak (513), coarseness (515), and Markovian textures (517) are analyzed and normalized, using mean and standard deviation, with respect to tissue taken from control subjects.
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