| 摘要 |
<p>Image guide methods and apparatus for ultrasound delivery of compounds through the blood brain barrier to selected locations in the brain, target a selected location in the brain of a patient (14), and apply ultrasound to effect in the tissues and/or fluids, at that location, a change detectable by imaging. At least a portion of the brain in the vicinity of the selected location is imaged, e.g., via magnetic resonance imaging to confirm the location of that change. A compound, e.g., a neuro-pharmaceutical in the patient's bloodstream, is delivered to the confirmed location by applying ultrasound to effect opening of the blood brain barrier at that location, and thereby to induce uptake of the compound there.</p> |
