NON-PEPTIDE BOMBESIN RECEPTOR ANTAGONISTS

摘要

Compounds of Formula (I) or a pharmaceutically acceptable salt thereof wherein Ar is phenyl or pyridyl unsubstituted or substituted. Ar<1> can be independently selected from Ar and can also include pyridyl-N-oxide, indolyl, imidazole, and pyridyl; R<3> can be independently selected from Ar or is hydrogen, hydroxy, NMe2, N-methyl-pyrrole, imidazole, tetrazole, thiazole (a), (b), (c) or (d), wherein Ar<2> is phenyl or pyridyl. The compounds of the instant invention are novel compounds which antagonize the bombesin receptors in mammals and are therefore effective in treating and/or preventing depression, psychoses, seasonal affective disorders, cancer, feeding disorders, gastrointestinal disorders, inflammatory bowel disease, sleep disorders, and memory impairment.