| 摘要 |
7 alpha -(xi-Aminoalkyl)-oestratriene derivatives of formula (I) and their acid-addition salts are new: SK = -(CH2)m-NA-CHB-CHD-(CH2)n-SOx-(CH2)3-E; m = 4-6; n, x = 0-2; A = H or 1-5C alkyl; B, D = H; or A+B = (CH2)p and D = H; or A+D = (CH2)q and B = H; p = 2-5; q = 2-4; E = optionally mono- to perfluorinated ethyl; R3 = H, 1-8C hydrocarbyl or COR3'; R3' = H, 1-8C hydrocarbyl or phenyl; R11 = H, halogen or ONO2; R14, R15a, R15b, R16a and R16b = H, or R14+R15a = a bond or a CH2 bridge, or R15b = Me and R15a = H, or R15a and R15b = Me, or R15b+R16b = a CH2 bridge, or R16a or R16b = halogen, or R16a+R16b = methylidene; and the remaining substituents from R14, R15a, R15b, R16a and R16b = H; R17' = H, 1-5C alkyl, 2-5C alkenyl, 2-5C alkynyl or CF3, or R17'+R14 = CH2CH2 when R17' is in the alpha position; R17" = H or COR17"'; R17"' = H or 1-8C hydrocarbyl; provided that, if A+B do not form (CH2)p or A+D do not form (CH2)q then R11, R14, R15a, R15a, R16a and R16b are not all H.
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| 申请人 |
SCHERING AG, 13353 BERLIN, DE |
发明人 |
BOHLMANN, ROLF, DR., 14055 BERLIN, DE;BITTLER, DIETER, 13503 BERLIN, DE;HEINDL, JOSEF, DIPL.-CHEM. DR., 14129 BERLIN, DE;HEINRICH, NIKOLAUS, DR., 12159 BERLIN, DE;HOFMEISTER, HELMUT, DIPL.-CHEM. DR., 13465 BERLIN, DE;KUENZER, HERMANN, DIPL.-CHEM. DR., 13347 BERLIN, DE;SAUER, GERHARD, DR., 13465 BERLIN, DE;HEGELE-HARTUNG, CHRISTA, DR., 10179 BERLIN, DE;LICHTNER, ROSEMARIE, DR., 10823 BERLIN, DE;NISHINO, YUKISHIGE, DR., 14089 BERLIN, DE;PARCZYK, KARSTEN, DR., 12207 BERLIN, DE;SCHNEIDER, MARTIN, PROF. DR., 13469 BERLIN, DE |
