发明名称 |
A PROCESS FOR PURIFYING APOLIPOPROTEIN A OR APOLIPOPROTEIN E FROM HUMAN PLASMA |
摘要 |
The present invention relates to a process for purifying apolipoprotein A (ApoA) or apolipoprotein E (ApoE) from human plasma, by obtaining a fraction of human plasma containing said ApoA or ApoE, prepurifying said fraction in at least one step, binding said ApoA or ApoE to an anion-exchange chromatography gel, and thereafter eluting said ApoA or ApoE from said anion-exchange chromatography gel. The thus produced ApoA or ApoE can be used for the manufacture of a medicament in the treatment of atherosclerosis and cardiovascular diseases, or peripheral atherosclerosis and sepsis as well as in a method for treatment of atherosclerosis and cardiovascular diseases, or peripheral atherosclerosis and sepsis when administered in a therapeutically effective amount.
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申请公布号 |
WO9807751(A1) |
申请公布日期 |
1998.02.26 |
申请号 |
WO1997SE01393 |
申请日期 |
1997.08.22 |
申请人 |
PHARMACIA & UPJOHN AB;WINGE, STEFAN;WIKLUND, SARA |
发明人 |
WINGE, STEFAN;WIKLUND, SARA |
分类号 |
A61K38/00;A61P9/00;A61P9/10;C07K1/18;C07K1/34;C07K14/755;C07K14/775;(IPC1-7):C07K14/775;C07K1/36 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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