发明名称 |
LATERAL FLOW MEMBRANE ARRANGEMENT AND LATERAL FLOW IMMUNOASSAY DEVICE COMPRISING THE SAME |
摘要 |
The present invention relates to a lateral flow membrane arrangement (1), comprising a microporous membrane layer (2) and a liquid-impermeable support layer (3), for lateral flow of a liquid through the microporous membrane layer (2), wherein the microporous membrane layer (2) is supported on the liquid-impermeable support layer (3) and has at least one detection zone (5) and at least one non-detection zone, wherein binding agents are immobilized in the at least one detection zone (5), the liquid-impermeable support layer (3) has at least one zone having a large thickness and at least one zone having a small thickness, the microporous membrane layer (2) is supported on the liquid-impermeable support layer (3) such that said at least one detection zone is provided above said at least one zone of the support layer having a large thickness and said at least one non-detection zone is provided above said at least one zone of the support layer having a small thickness, the zones are oriented in a direction orthogonally to the lateral flow direction (a) of said liquid, the detection zone (5) has a thickness (7) of 100 to 150 μm over the entire width of the membrane, the non-detection zone has a thickness (8) of at most 300 μm over the entire width of the membrane, and the lateral flow membrane arrangement (1) has a constant thickness (9), as well as to a lateral flow immunoassay device comprising said membrane arrangement (1). |
申请公布号 |
US2016178640(A1) |
申请公布日期 |
2016.06.23 |
申请号 |
US201414910711 |
申请日期 |
2014.04.29 |
申请人 |
SARTORIUS STEDIM BIOTECH GMBH |
发明人 |
MELZNER Dieter;VAN ROSSUM Denise |
分类号 |
G01N33/68;B05D3/00;B05D1/02;B05D3/06;G01N33/558;G01N33/76 |
主分类号 |
G01N33/68 |
代理机构 |
|
代理人 |
|
主权项 |
1. A lateral flow membrane arrangement, comprising a microporous membrane layer and a liquid-impermeable support layer, for lateral flow of a liquid through the microporous membrane layer, wherein
the microporous membrane layer is supported on the liquid-impermeable support layer and has at least one detection zone and at least one non-detection zone, wherein binding agents are immobilized in the at least one detection zone, the liquid-impermeable support layer has at least one zone having a large thickness and at least one zone having a small thickness, the microporous membrane layer is supported on the liquid-impermeable support layer such that said at least one detection zone is provided above said at least one zone of the support layer having a large thickness and said at least one non-detection zone is provided above said at least one zone of the support layer having a small thickness, the zones are oriented in a direction orthogonally to the lateral flow direction (a) of said liquid, the detection zone has a thickness of 100 to 150 pm over the entire width of the membrane, the non-detection zone has a thickness of at most 300 pm over the entire width of the membrane, and the lateral flow membrane arrangement has a constant thickness. |
地址 |
Göttingen DE |