摘要 |
What is described are pharmaceutical compositions comprising a double-stranded nucleic acid molecule comprising a sense strand and an antisense strand wherein the sense and antisense strands are selected from the oligonucleotides described as SERPINH1_2 (SEQ ID NOS: 60 and 127), SERPINH1_45a (SEQ ID NOS: 98 and 165), and SERPINH1_51 (SEQ ID NOS: 101 and 168), and drug carrier comprising a mixture of a retinoid and a lipid vesicle, and methods of using these pharmaceutical compositions to treat a disease associated with hsp47 espresssion, including fibrosis. |
申请人 |
Nitto Denko Corporation |
发明人 |
MINOMI, Kenjiro;TANAKA, Yasunobu;FEINSTEIN, Elena;AVKIN-NAHUM, Sharon;KALINSKi, Hagar;METT, Igor;PAYNE, Joseph E.;KNOPOV, Victor;WITTE, Richard P.;YING, Wenbin;LIU, Yun;PERELMAN, Loren A.;AKOPIAN, Violetta;NIITSU, Yoshiro;AHMADIAN, Mohammad |