摘要 |
A process for the preparation of an N,N-disubstituted-2-fluoro-1,3-ketoamide having the formula RCO.CFR'CONR2'' comprises treating an N,N-disubstituted-1,3-ketoamide having the formula RCO.CHR'CONR2'' with elemental fluorine. The groups R, R' and R'' are independently selected from alkyl, aryl, substituted aryl, cycloalkyl, and substituted cycloalkyl. The group R' may also be nitro or chlorine. |