发明名称 |
Plasminogen activator capable of being activated by thrombin |
摘要 |
A plasminogen activator (t-PA) is (a) modified in such a way that it can be split by thrombin and thus turned into its two-chain form; (b) modified in such a way that its zymogenity is at least 1.2 higher than that of t-PA; and (c) its fibrin binding power is so reduced that more than 50 % of the plasminogen activator can enter a blood clot. This plasminogen activator has an improved fibrin-specificity and less side effects. |
申请公布号 |
AU3769797(A) |
申请公布日期 |
1998.02.25 |
申请号 |
AU19970037697 |
申请日期 |
1997.07.21 |
申请人 |
BOEHRINGER MANNHEIM G.M.B.H. |
发明人 |
ULRICH KOHNERT;STEPHAN FISCHER |
分类号 |
C12N15/09;A61K8/00;A61K38/00;A61K38/46;A61K38/49;A61Q1/00;A61Q1/02;C12N1/21;C12N9/64;C12N9/72 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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