发明名称 |
Thienotriazolodiazepine compound and pharmaceutical use thereof |
摘要 |
N-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno [3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl )-N'- (2-methoxyphenyl)urea, optical isomers thereof and pharmaceutically acceptable salts thereof. The compounds of the present invention strongly and selectively inhibit the expression of VCAM-1 and have an inhibitory effect on leukocyte adhesion to vascular endothelial cells. Accordingly, the compounds of the present invention can be used as cell adhesion inhibitors for prophylaxis or treatment of various diseases in which cell adhesion is involved in the onset and progress thereof.
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申请公布号 |
US5721231(A) |
申请公布日期 |
1998.02.24 |
申请号 |
US19950535913 |
申请日期 |
1995.09.28 |
申请人 |
YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. |
发明人 |
MORIWAKI, MINORU;KITANI, HIROYUKI;EHARA, SYUJI;KOMATSU, HIROTSUGU;AMANO, MARIKO |
分类号 |
C07D495/14;(IPC1-7):A61K31/55 |
主分类号 |
C07D495/14 |
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地址 |
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