Pyrazole derivatives

摘要

PCT No. PCT/JP94/00587 Sec. 371 Date Sep. 29, 1995 Sec. 102(e) Date Sep. 29, 1995 PCT Filed Apr. 7, 1994 PCT Pub. No. WO94/22838 PCT Pub. Date Oct. 13, 1994Pyrazole compounds of formula [1] and their tautomers and salts: <IMAGE> [1] (wherein R1 is an alkyl group, etc.; R2 is a carboxyl group, etc.; R3 is a halogen atom, an alkyl group, a phenyl group, etc.; R4, R5 and R6 each are a hydrogen atom, a halogen atom, etc.; R7 is a carboxyl group, a 5-tetrazolyl group, etc.; X is a nitrogen atom, etc.; Y and Z each are CH, a nitrogen atom, etc.; A and E each are a methylene group, etc.; D is a phenyl group, etc.; G is a covalent bond, etc.). The compounds of the invention have an antagonistic effect against angiotensin II and are useful for prevention and remedy of hypertension, congestive cardiac insufficiency, chronic renal insufficiency, aldosteronism, hyper-intraocular pressure, etc.