| 摘要 |
PCT No. PCT/EP94/00333 Sec. 371 Date Jul. 19, 1995 Sec. 102(e) Date Jul. 19, 1995 PCT Filed Feb. 7, 1993 PCT Pub. No. WO94/19019 PCT Pub. Date Sep. 1, 1994A process for producing solutions of active substances of low solubility, which comprises (1) dissolving the active substance with a phospholipid and a water-soluble lipid in an organic solvent, (2) evaporating the resulting solution to dryness, (3) taking up the residue in a strongly acidic buffer and stirring at elevated temperature until a colloidal solution is produced, (4) cooling the colloidal solution and adjusting to a pH of 6-7 and sterilizing. Particularly suitable for the process are lipids of the formula <IMAGE> I wherein m, a, b, x and y have the meanings indicated in the description.
|
