发明名称 Monoclonal antibodies directed to the HER2 receptor
摘要 A method of inhibiting growth of tumor cells which overexpress a growth factor receptor or growth factor by treatment of the cells with antibodies which inhibit the growth factor receptor function, is disclosed. A method of treating tumor cells with antibodies which inhibit growth factor receptor function, and with cytotoxic factor(s) such as tumor necrosis factor, is also disclosed. By inhibiting growth factor receptor functions tumor cells are rendered more susceptible to cytotoxic factors.
申请公布号 US5720954(A) 申请公布日期 1998.02.24
申请号 US19950449383 申请日期 1995.05.23
申请人 GENENTECH, INC. 发明人 HUDZIAK, ROBERT M.;SHEPARD, H. MICHAEL;ULLRICH, AXEL;FENDLY, BRIAN M.
分类号 A61K31/00;A61K31/365;A61K31/366;A61K31/40;A61K31/407;A61K31/505;A61K31/519;A61K31/529;A61K31/70;A61K31/7008;A61K33/24;A61K38/00;A61K38/21;A61K39/395;A61K45/00;A61K47/48;A61P35/00;A61P43/00;C07K1/22;C07K14/00;C07K14/485;C07K14/495;C07K14/52;C07K14/525;C07K14/54;C07K14/545;C07K14/55;C07K14/555;C07K14/57;C07K14/705;C07K14/715;C07K16/00;C07K16/22;C07K16/28;C07K16/30;C07K16/32;C07K19/00;C12N5/10;C12N15/02;C12P21/08;C12R1/91;G01N33/573;G01N33/574;G01N33/577;(IPC1-7):A61K39/00 主分类号 A61K31/00
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