发明名称 |
Assembly-deficient herpesvirus vaccine |
摘要 |
A vaccine is described which comprises an assembly-deficient herpesvirus. The mutant herpesvirus is capable of infecting and undergoing DNA replication in the cells of a susceptible mammal, but is defective in capsid assembly and formation of mature virion particles. The assembly-deficient herpesvirus is avirulent and capable of generating a protective immune response in a vaccinated mammal. |
申请公布号 |
AU3977997(A) |
申请公布日期 |
1998.02.20 |
申请号 |
AU19970039779 |
申请日期 |
1997.07.25 |
申请人 |
G. D. SEARLE & CO. |
发明人 |
PAUL J. HIPPENMEYER;ANNE M. RANKIN;VERNE A LUCKOW |
分类号 |
C12N15/09;A61K38/46;A61K39/00;A61K39/245;A61K48/00;A61P31/22;C12N5/10;C12N7/00;C12N9/50;C12N15/52;C12R1/92 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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