发明名称 |
Fremgangsmåde til behandling og bioassay involverende makrofagmigrationshæmmende faktor (MIF) som hjerteafledt myokardiedepressionsfaktor |
摘要 |
An embodiment of the present invention relates to a pharmaceutical composition, which includes a therapeutically effective amount of at least one anti-MIF antibody; and at least on pharmaceutically acceptable carrier. Another embodiment of the present invention relates to a pharmaceutical composition, which includes a therapeutically effective amount of at least one anti-CD74 antibody; and at least one pharmaceutically acceptable carrier. Another embodiment of the present invention relates to a pharmaceutical composition, which includes a therapeutically effective amount of at least one anti-TNFR antibody; a therapeutically effective amount of at least one anti-MIF antibody; and at least one pharmaceutically acceptable carrier. Other embodiments of the present invention relate to methods of treating or preventing cardiac dysfunction, cardiodepression, burn injury-associated cardiac dysfunction, improving cardiac function in a subject following acute myocardial infarction and identifying an MIF inhibitor. |
申请公布号 |
DK1658037(T3) |
申请公布日期 |
2016.08.29 |
申请号 |
DK20040782427T |
申请日期 |
2004.08.30 |
申请人 |
Baxter International Inc.;Baxter Healthcare SA;BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
GIROIR, Brett;WILLIS, Monte;DE LA CRUZ, Vidal;SIELECKI, Thais |
分类号 |
C07K16/24;A61K;A61K39/00;A61K39/395;C07K16/28 |
主分类号 |
C07K16/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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