COMPOSITIONS AND METHODS FOR DELIVERY OF NUCLEIC ACIDS TO HEPATOCYTES

摘要

Disclosed are recombinant baculoviruses that are used to deliver hepatocyte expressable nucleic acid constructs specifically to hepatocytes. Also provided are a variety of recombinant baculovirus vectors which comprise at least one oligosaccharide processing enzyme gene and a hepatocyte expressible nucleic acid segment. The invention also provides methods of using the expression systems and recombinant baculoviruses, particularly in the treatment of liver diseases and/or infections.