SPATIAL AND TEMPORAL CONTROL OF GENE EXPRESSION USING A HEAT SHOCK PROTEIN PROMOTER IN COMBINATION WITH LOCAL HEAT

摘要

The invention provides methods for using local heat to control gene expression. The heat shock protein (hsp) gene promoter is recombined with a selected therapeutic gene and expressed in selected cells. Local controlled heating is used to activate the hsp promoter, for example by using focused ultrasound controlled by MRI.