发明名称 |
MELANOMA CELL LINES EXPRESSING SHARED IMMUNODOMINANT MELANOMA ANTIGENS AND METHODS OF USING SAME |
摘要 |
The invention pertains to a method of treating or protecting against melanoma that comprises (a) obtaining a melanoma cell line that expresses one or more shared immunodominant melanoma antigens, (b) modifying the melanoma cell line to render it capable of producing an increased level of a citokyne relative to the unmodified cell line, and (c) administering the melanoma cell line to a mammalian host that has melanoma or is at risk for developing melanoma. Preferably the melanoma cell line is allogenic and is not MHC-matched to the host.
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申请公布号 |
CA2263503(A1) |
申请公布日期 |
1998.02.19 |
申请号 |
CA19972263503 |
申请日期 |
1997.08.04 |
申请人 |
UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES;THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE |
发明人 |
PARDOLL, DREW M.;JAFFEE, ELIZABETH M.;ADLER, ADAM;ROSENBERG, STEVEN A.;TOPALIAN, SUZANNE L. |
分类号 |
A61K48/00;A61K35/12;A61K39/00;A61P35/00;(IPC1-7):A61K39/00 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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