发明名称 |
EXPRESSION VECTORS, CELLS, AND METHODS FOR PREPARING THROMBOPOIETIN POLYPEPTIDES |
摘要 |
Thrombopoietin polypeptides and vectors, cells, and methods for making the polypeptides are disclosed. The polypeptides are characterized by an amino acid backbone consisting of C-X-B, wherein C is a human thrombopoietin cytokine domain polypeptide; X is a peptide bond or a linker consisting of one or two amino acid residues, subject to the limitation that X, alone or in combination with C or B, does not provide a dibasic amino acid pair; and B is a polypeptide consisting of residues 1 to y of SEQ ID NO:3, wherein y is an integer from 5 to 18, and wherein up to 35 % of the amino acid residues of B are individually replaced by other amino acid residues. The polypeptides are useful with methods of stimulating proliferation or development of hematopoietic cells in vitro and in vivo.
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申请公布号 |
WO9806849(A1) |
申请公布日期 |
1998.02.19 |
申请号 |
WO1997US13543 |
申请日期 |
1997.07.30 |
申请人 |
ZYMOGENETICS, INC. |
发明人 |
IRANI, MEHER;MORRISON-NELSON, GARY, R. |
分类号 |
C12N15/09;A61K38/00;A61P7/00;C07K14/52;C12N1/19;C12N15/19;C12P21/02;(IPC1-7):C12N15/19;C12N15/62;C12N15/81;A61K38/19 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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