发明名称 PROCESS FOR PREPARING RECOMBINANT INSULIN USING MICROFILTRATION
摘要 The use of two tandem microfiltration (MF) steps in a process for making recombinant insulin is described. The two MF steps in a single downstream purification unit operation reduce both soluble and insoluble impurities and exchange the insulin product into a suitable buffer for downstream purification.
申请公布号 WO2016144658(A1) 申请公布日期 2016.09.15
申请号 WO2016US20534 申请日期 2016.03.03
申请人 MERCK SHARP & DOHME CORP.;GANT, Sean, S.;IAMMARINO, Michael, J.;KERCHNER, Kristi;RAUSCHER, Michael, A.;ROUSH, David, J.;SMITH, Christopher, H.;CHANDLER, Martin;PETROFF, Matthew 发明人 GANT, Sean, S.;IAMMARINO, Michael, J.;KERCHNER, Kristi;RAUSCHER, Michael, A.;ROUSH, David, J.;SMITH, Christopher, H.;CHANDLER, Martin;PETROFF, Matthew
分类号 C07K14/62;C12N9/50;C12N15/09;C12P21/00;C12P21/06 主分类号 C07K14/62
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