New ((hetero)aryl-alkyl)amino-steroid derivatives

摘要

Steroidal derivatives of formula (I) are new. A = anion, preferably F, Cl, Br, I, acetate trifluoroacetate; R = steroidal skeleton from cholane, cardenolide or bufadienolide derivative; a = 0 or 1; R1 = H, alkyl or aryl, and may also be acyl or (CH2)yR3 when a = 0; R2 = H; or when a = 0, R1+R2 may also be a bond; R3 = (CH2)xR6; R4 = H, alkyl or R3; R5 = H, alkyl or (CH2)yR7; R6, R7 = independently phenyl (optionally mono- to penta-substituted by R'), heteroaryl (preferably pyridyl, pyrrolyl, furanyl, thiophenyl, all optionally substituted by one or more OH or R') or a metallocene such as ferrocenyl (optionally substituted by one or more alkyl, aryl); R' = halogen, NO2, alkoxy, aryloxy, acyloxy, acyl, alkyl, aryl or heteroaryl; and x, y /- 0.