The invention provides improved oligonucleotides having greater resistance to nucleolytic degradation by virtue of having alkylphosphonothioate or arylphosphonothioate internucleotide linkages.
申请公布号
DE69316369(D1)
申请公布日期
1998.02.19
申请号
DE1993616369
申请日期
1993.07.26
申请人
HYBRIDON, INC., WORCESTER, MASS., US
发明人
PADMAPRIYA, A., SHREWSBURY, MA 01545, US;AGRAWAL, SUDHIR, SHREWSBURY, MA 01545, US