发明名称 |
Improvements in detection systems and methods for predicting the dissolution curve of a drug from a pharmaceutical dosage form |
摘要 |
The present invention relates to an improvement in a detection system used for continuously measuring the release of a drug from a pharmaceutical dosage form comprising a singular dissolution vessel or multiple dissolution vessels containing a dissolution medium and a measuring device for detecting the amount of drug released at a given time, the improvement comprising a mixing shaft and a probe placed within the mixing shaft or outside the individual dissolution vessels, the probe capable of measuring the dissolution characteristics using UV, IR, near-IR, fluorescence, electrochemical, and Raman spectroscopy techniques. The present invention also relates to a method for predicting the dissolution curve provided by a controlled release pharmaceutical dosage form comprising taking continuous measurements of the amount of drug released from a dosage form for a portion of the time over which the drug is expected to be released and predicting the remainder of the dissolution curve based on the values obtained. |
申请公布号 |
WO9746860(A3) |
申请公布日期 |
1998.02.19 |
申请号 |
WO1997US11791 |
申请日期 |
1997.06.04 |
申请人 |
EUROCELTIQUE S.A.;ROINESTAD, KURT;CHENG, FRANK, S.;PALERMO, PHILIP, J.;BYNUM, KEVIN |
发明人 |
ROINESTAD, KURT;CHENG, FRANK, S.;PALERMO, PHILIP, J.;BYNUM, KEVIN |
分类号 |
G01N21/64;A61K9/00;G01N13/00;G01N21/33;G01N21/35;G01N21/65;G01N33/15 |
主分类号 |
G01N21/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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