PROCESS FOR PREPARING ALKYL ESTER OF CHLORONITROPHENYLACETIC ACID

摘要

There is described a novel process for the preparation of 5-chlorooxindole starting from p-chloronitrobenzene. In this process, in the first step chloronitrobenzene of the formula … … is converted with an alkyl chloroacetate of the general formula … … in the presence of a base to an alkyl chloronitrobenzeneacetate of the general formula … … this is hydrogenated catalytically in the second step with hydrogen to give the corresponding amine of the general formula … … and this is then cyclised in the third step in the presence of an acid to give the final product according to the formula … …