发明名称 |
4,7-dialkoxy N-acetylneuraminic acid derivatives and methods for detection of influenza type A and B viruses in clinical specimens |
摘要 |
Chromogenic and fluorogenic 4,7-dialkoxy-N-acetylneuraminic acid substrates of the general formula l groups containing 1 to 4 carbon atoms and R3 is a chromogenic or fluorogenic group. These substrates can be used to detect influenza types A and B in clinical samples or specimens. More particularly, these 4,7-dialkoxy-N-acetylneuraminic acid substrates can be used to distinguish between various viruses having neuraminidase reactivity. Thus, influenza type A and B viruses can be distinguished from parainfluenza type 1, 2, 3, and 4, and mumps using the 4,7-dialkoxy-N-acetylneuraminic acid derivatives of this invention. Diagnostic methods employing these substrates are provided to identify influenza type A and B viruses in clinical specimens and to distinguish from other viruses having neuraminidase reactivity.
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申请公布号 |
US5719020(A) |
申请公布日期 |
1998.02.17 |
申请号 |
US19960718666 |
申请日期 |
1996.09.25 |
申请人 |
OKLAHOMA MEDICAL RESEARCH FOUNDATION |
发明人 |
LIAV, AVRAHAM;HANSJERGEN, JOYCE ANNE;SHIMASAKI, CRAIG DAVID |
分类号 |
C12Q1/04;C07H7/027;C07H15/04;C07H15/203;C07H17/02;C07H17/075;C12Q1/34;C12R1/92;G01N33/569;(IPC1-7):C12Q1/70;C07H1/00;C07H15/00;C12N9/26 |
主分类号 |
C12Q1/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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