发明名称 SYNTHETIC TAXOL USING FOR PRESERVATING INTERNAL ORGAN AND AS HEART-PARALYTIC DRUG
摘要 PROBLEM TO BE SOLVED: To obtain a synthetic product useful for preservating and storing interal organs prior to the transplantation to patients who need the transplantation by containing a specific compound and calcium in a physiologically acceptable preservative liquid for external use for internal organs. SOLUTION: This physiological acceptable preservative liquid for external use for internal organs contains taxol of the formula and calcium in a preservative liquid or a sprinkling liquid for internal organs or in a heart-paralytic drug. Further, it possesses a capacity osmolarity of about 320mOsm/l and taxol, calcium and lactobionic acid salt may be contained in the preservative liquid. This preservative liquid possesses a molecular weight of about 150,000Da to about 350,000Da and is preferably composed of substantially ethylene glycol, ethylene chlorohydrin, sodium chloride and about 3-8wt.% of hydroxyethyl starch containing no acetone. Taxol is preferably covered with liposome. Taxol and calcium are contained in amounts of about 1nM to about 100nM and about 0.5μM to 1.5μM, respectively.
申请公布号 JPH1045502(A) 申请公布日期 1998.02.17
申请号 JP19970114724 申请日期 1997.05.02
申请人 WISCONSIN ALUMNI RES FOUND 发明人 SOUTHARD JAMES H
分类号 C07D305/14;A01N1/02;A61K31/335;A61K31/337;A61P9/00;(IPC1-7):A01N1/02 主分类号 C07D305/14
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