| 摘要 |
<p>NEW MATERIAL:A polypeptide (salt) expressed by formula I [A is formula II (G is L- or DC-type basic amino acid; R<2> and R<3> are H, lower alkyl or acyl), etc.; B is L-type basic amino acid, etc.; C is L-type Pro, etc.; D is L-type (non)natural type aromatic amino acid; E is L-type (N-alkyl)amino acid, etc. ; F is L- or D-type (N-alkyl)amino acid, etc.; R<1> is formula III (R<7> and R<8> are H, lower alkyl), etc.]. USE:An antipsychotic and analgesic agents. PREPARATION:For example, ethyl ester of a C-terminal amino acid, etc., are reacted with an amino acid having a protected alpha-amino group at the second position from the C-terminal in the presence of N-methylmorpholine and ethyl chlorocarbonate, etc., and the alpha-amino-protecting group is then removed. The similar operation is repeated according to an amino acid sequence of a peptide to afford the peptide expressed by formula I.</p> |
