ACYLPYRROLDICARBOXYLIC ACIDS AND ACYLINDOLDICARBOXYLIC ACIDS AND THEIR DERIVATIVES AND INHIBITORS OF THE CYTOSOLIC PHOSPHOLIPASE A2

摘要

New antiphlogistic and analgesic agents are disclosed having the formulas (I) and (II). These new compounds have an improved inhibiting effect and/or less cytotoxicity as compared with the compounds known from the prior art. The disclosed compounds are remarkably suitable to prevent and/or treat diseases caused or aggravated by an increased activity of the phospholipase A2 enzyme, such as inflammations, allergies, asthma, psoriasis and endotoxin shock.