AMINO COMPOUNDS AND ANGIOTENSIN IV RECEPTOR AGONISTS

摘要

Amino compounds represented by general formula (1) or pharmaceutically acceptable salts thereof: (wherein X represents CH2NH or CONH; Y represents CH2NH or CONH, provided that X and Y do not represent CONH at the same time; Z represents CH=C(R4)R5, CH2CH(R4)R5 or alkoxycarbonyl (wherein R4 and R5 independently represent each hydrogen or optionally substituted alkyl, aralkyl, aryl or heteroaryl); R1 represents hydrogen or optionally substituted lower alkyl, cycloalkyl, cycloalkyl-substituted alkyl, aralkyl or aryl; and R2 and R3 independently represent each optionally substituted lower alkyl or aralkyl); drugs composed of the amino compounds of general formula (1) or pharmaceutically acceptable salts thereof; and angiotensin receptor agonists containing the same as the active ingredient. These drugs are useful as remedies such as antagonists or agonists for various pathological states in which angiotensin IV participates, for example, accelerated renal blood flow, cerebral vasodilation, cell proliferation inhibition or hypermnesia.