摘要 |
<p>A phosphonic acid derivative compound represented by formula [I] or a pharmaceutically acceptable salt thereof: <CHEM> wherein R1, R2 and R3 each represent hydrocarbon groups which may be substituted, except cases in which (1) R2 is unsubstituted methyl, (2) R3 is an unsubstituted hydrocarbon group having 1 to 3 carbon atoms, and (3) R1 is benzyloxycarbonylaminomethyl, R2 is isobutyl and R3 is isobutyl or phenylmethyl, which has endothelin-converting enzyme inhibiting activity and is useful as pharmaceutical drugs such as therapeutic agents for hypertension, cardiac or cerebral circulatory diseases and renal diseases.</p> |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD., OSAKA, JP |
发明人 |
WAKIMASU, MITSUHIRO, TSUKUBA, IBARAKI 305, JP;MORI, MASAAKI, TSUKUBA, IBARAKI 305, JP;KAWADA, AKIRA, TSUCHIURA, IBARAKI 300, JP |