INTERMEDIATES FOR OLIGONUCLEOTIDE SYNTHESIS

摘要

A compound of formula (I) where B<1> is a radical of a nucleoside base, R<1> is hydrogen or a hydroxy-protecting group, R<2> is hydrogen, hydroxy or a 2' nucleoside-modifying atom or group, R<3> is an unsubstituted or substituted C1 to C10 alkyl, C2 to C10 alkenyl, C4 to C10 cycloalkylalkyl, C6 to C10 aryl or C7 to C13 aralkyl group, and Z is halogen or a group of formula (II) where R<4> and R<5> are each independently an unsubstituted or substituted C1 to C10 alkyl, C2 to C10 alkenyl, C4 to C10 cycloalkylalkyl, C6 to C10 aryl or C7 to C13 aralkyl group, or R<4> is said group and R<5> is hydrogen, or R<4> and R<5> together with the nitrogen atom to which they are attached denote a five- to thirteen-membered heterocyclic ring, or Z is a group of formula (III): Nuc-O-, where Nuc is the residue of a natural or synthetic nucleoside or oligonucleotide after removal of a 5'-hydroxyl group therefrom attached through a 5' methylene thereof to the indicated oxygen atom. 00000