| 摘要 |
PROBLEM TO BE SOLVED: To prepare a new compound useful for treating diseases caused by estrogen deficiency. SOLUTION: This new compound is represented by formula I or II [R1 is H, OH, a 1-12C ester, etc.; R2 to R6 are each H, OH, a 1-12C alkyl ether, etc., with the proviso that R2 is not OH when R1 is H; X is H, a 1-6C alkyl, etc.; (n) is 2 or 3; Y is represented by formula III (R7 and R8 are each H, a 1-6C alkyl, etc.), etc.], e.g. 5-benzyloxy-2-(4-ethoxy-phenyl)-3-methyl-1-[4-(2-piperidin-1- yl-ethoxy)-benzyl]-1H-indole. The compound represented by formula I is prepared by reacting an aniline represented by formula IV with anα-bromoketone represented by formula V in dimethylformamide, providing a substituted indole and then reacting the resultant substituted indole with benzyl chloride in the presence of NaH.
|
